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“病入膏肓”，汉语成语，字面意思是“the disease has spread to the vital organs”，指病到无法医治的地步，也比喻事情到了无可挽回的地步。可以翻译为“be beyond cure/recovery，be incurably ill，be at death’s door from illness”等。
例句：
这个病人已病入膏肓，没有多少痊愈的希望了。
The patient has contracted a fatal illness. There is little chance of his recovery.
我不得不说你病入膏肓了。
I have to say you are incurable.